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Developmental Care: Neonatal Pain

Neonatal Pain Management.

Non-pharmacological Tactics for Managing Pain in the NICU.

Offering developmental support can help a neonate cope with its pain. Interventions that help an infant stay organized and transition to a change in its situation will also leave it better physiologically prepared for pain. Several non-pharmologic tactics can be used along with or without pharmacologic intervention:
  • Whenever possible keep the baby in a tucked, flexed position.(3) Swaddling (with hands or blankets) can be used instead of using limb restraints (what I refer to as being 'drawn and quartered'). For umbilical catheter placement legs and arms can be swaddled separately, leaving the abdomen exposed; a diaper can be wrapped around a baby's lower extremities and buttocks (rather than through the legs) and taped to assist in swaddling while leaving the abdomen exposed for umbilical line placement. A blanket folded lengthwise can prevent the infant from raising his legs during the procedure. Lay the blanket across the legs and tuck it in under the sides of the mattress. For peripheral IV, arterial line placement, heel stick or venipuncture, leave the limb to be worked on out and place the baby on her side.
  • Enlist the help of another nurse who can help soothe the infant, offer a pacifier and position the baby in a developmentally supportive manner.
  • Maintain the environment that supports the infant (provide quiet, warmth, shield from light, etc.). When an infant becomes sick it is often those times when we focus on getting the job done which may include quickly repositioning the baby, putting on bright lights and increasing the noise level. Unfortunately, it is also the time when the infant is least able to handle this stimuli.
  • Choose the less painful way to give care. For instance, endotracheal suctioning need not be done with every care time but only when needed; and, venipuncture is less painful than a heel stick (2) although when a sick infant is requiring frequent IVs these sites may need to be saved. Where feasible, transcutaneous monitoring may reduce the need for blood draws.
  • Sucrose is given on the tip of the tongue a couple of minutes before minor procedures. Some references consider it pharmacologic and others consider sucrose non-pharmacologic. Regardless, it is an effective alternative to opiates and sedatives for acute pain. Sucrose may require a doctor's order and documentation on the patient's MAR. Typical dosing is 1-2mls. Experience shows that some babies will require only a drop or two on the tip of the tongue while others will require more. A swab soaked in sucrose can be used on the tip of the tongue of patients at risk for aspiration. Careful consideration should be taken before giving sucrose to infants with GI disturbances or micropremies (increased risk of necrotizing enterocolitis).(3) Infants who are not candidates for sucrose will still benefit from non-nutritive sucking.

Despite the current concensus that neonates have pain there can be a lot of variation in how it is approached - which sedatives and narcotics are used and how they are administered. There are a lot of pros and cons to be considered when providing pain relief in the form of drugs. There is evidence that ventilated micropremies given low-dose continuous morphine are less likely to experience intraventricular hemorrhage. (2) Studies suggest that morphine needs to be given longterm (14 days vs. 7 days) to have this affect.(3) On the other hand, neonates treated with sedatives and narcotics have shown an increased tendency to addiction later in life, (1) and, as many seasoned NICU nurses have seen, poorly controlled narcotic withdrawal (either from NICU use or maternal use) can be a painful condition in itself. Midazolam use has not shown the same decrease in the incidence of IVH as morphine, however, while sedatives do not treat pain, they can be used along with opiates for sedation and amnesia.(2) Benzodiazepines are associated with hypotension, apnea and twitchiness. It's also not uncommon to see a baby who has been receiving significant doses of midazolam get the hiccups. Opiates are also not without side effects. They also can cause apnea and hypotension. Morphine is known for slowing down the gut and causing urinary retention. Fentanyl, given too fast, is associated with chest wall rigidity. Although, it is my belief that they should never be withheld when needed, opiate use needs to be moderated and alternative interventions used whenever possible. For minor procedures oral sucrose has proven to be an effective way to relieve pain.(1) The effectiveness of acetaminophen has been shown to be best in continuous pain (rather than acute pain) and as an adjunct to opiates in post-operative pain. It not recommended for use with gestations less than 28 weeks and oral administration has shown more consistent absorption than rectal administration.(3)


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Resources.

1. Anand, K. J. S. and Frank M. Scalzo. February 2000. "Can Adverse Neonatal Experiences Alter Brain Development and Subsequent Behavior?" Biology of the Neonate, Volume 77, Number 2: Pages 69-82.
2. Association of Women's Health, Obstetric and Neonatal Nurses (AWHONN). 2002. "Assessment and Management of Acute Pain in the Newborn." Web Continuing Education Resource.
3. American Academy or Pediatrics (AAP). November 2006. "Prevention and Management of Pain in the Neonate: An Update." Policy Statement. Pediatrics Vol. 118 No. 5, pp. 2231-2241


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